Risk of acute kidney injury in patients with HIV receiving proton pump inhibitors-Reference-Cited by-同舟云学术

Risk of acute kidney injury in patients with HIV receiving proton pump inhibitors

Published:2019-07 Issue:10 Volume:8 Page:781-790
ISSN:2042-6305
Container-title:Journal of Comparative Effectiveness Research
language:en
Short-container-title:Journal of Comparative Effectiveness Research

Author:

Sutton S Scott¹²^ORCID,Magagnoli Joseph²,Cummings Tammy H²,Hardin James W³

Affiliation:

1. Department of Clinical Pharmacy & Outcomes Sciences, South Carolina College of Pharmacy, University of South Carolina, 715 Sumter Street (CLS 314b), Columbia, SC 29208-0001, USA

2. Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, SC 29209, USA

3. Department of Epidemiology & Biostatistics, Biostatistics Division, University of South Carolina, 1600 Hampton Street, Suite 507, Room 539, Columbia, SC 29208-3400, USA

Abstract

Aims/patients & methods: To evaluate the risk of acute kidney injury (AKI) in patients with HIV receiving proton pump inhibitors (PPI) a cohort study was conducted utilizing the Veterans Affairs Informatics and Computing Infrastructure (VINCI) database. Patients were followed from the index date until the earliest date of AKI, 120 days or end of study period, or death. Statistical analyses utilized a Cox proportional hazards model. Results: A total of 21,643 patients (6000 PPI and 15,643 non-PPI) met all study criteria. The PPI cohort had twice the risk of AKI compared with controls (2.12, hazard ratio: 1.46–3.1). Conclusion: A nationwide cohort study supported the relationship of an increased risk of AKI in patients receiving PPIs.

Publisher

Future Medicine Ltd

Subject

Health Policy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/cer-2019-0017

Reference58 articles.

1. All-cause mortality in treated HIV-infected adults with CD4 >=500/mm3 compared with the general population: evidence from a large European observational cohort collaboration

2. Acute Kidney Injury in HIV-Infected Patients

3. Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality

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