Systematic literature review of evidence in amyloid light-chain amyloidosis

Author:

Lee Charlene1,Lam Annette1,Kangappaden Teresa2,Olver Pyper2,Kane Sarah2,Tran Diana2ORCID,Ammann Eric1ORCID

Affiliation:

1. Janssen Global Services, LLC, Raritan, NJ 08869, USA

2. EVERSANA Life Science Services, LLC, Burlington, ON, L7N 3H8, Canada

Abstract

Introduction: Treatment of amyloid light-chain (AL) amyloidosis, a rare disease with a <5-year lifespan, remains challenging. This systematic literature review (SLR) aimed to evaluate the current evidence base in AL amyloidosis. Methods: Literature searches on clinical, health-related quality of life, economic and resource use evidence were conducted using the Embase, MEDLINE and Cochrane databases as well as gray literature. Results: This SLR yielded 84 unique studies from: five randomized controlled trials; 54 observational studies; 12 health-related quality of life studies, none with utility values; no economic evaluation studies; and 16 resource use studies, none with indirect costs. Conclusion: This SLR highlights a paucity of published literature relating to randomized controlled trials, utility values, economic evaluations and indirect costs in AL amyloidosis.

Funder

Janssen Global Services

Publisher

Becaris Publishing Limited

Subject

Health Policy

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