Nanoparticle conversion to biofilms: in vitro demonstration using serum-derived mineralo-organic nanoparticles-Reference-Cited by-同舟云学术

Nanoparticle conversion to biofilms: in vitro demonstration using serum-derived mineralo-organic nanoparticles

Published:2015-12 Issue:24 Volume:10 Page:3519-3535
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Wong Tsui-Yin¹²,Peng Hsin-Hsin¹²,Wu Cheng-Yeu¹²³,Martel Jan¹²,Ojcius David M²⁴,Hsu Fu-Yung⁵,Young John D¹²⁶⁷

Affiliation:

1. Laboratory of Nanomaterials, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan

2. Center for Molecular & Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan

3. Research Center of Bacterial Pathogenesis, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan

4. Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA 94103, USA

5. Department of Materials Engineering, Ming Chi University of Technology, Taishan, New Taipei City 24301, Taiwan

6. Laboratory of Cellular Physiology & Immunology, Rockefeller University, New York, NY 10021, USA

7. Biochemical Engineering Research Center, Ming Chi University of Technology, Taishan, New Taipei City 24301, Taiwan

Abstract

Aims: Mineralo-organic nanoparticles (NPs) detected in biological fluids have been described as precursors of physiological and pathological calcifications in the body. Our main objective was to examine the early stages of mineral NP formation in body fluids. Materials & methods: A nanomaterial approach based on atomic force microscopy, dynamic light scattering, electron microscopy and spectroscopy was used. Results: The mineral particles, which contain the serum proteins albumin and fetuin-A, initially precipitate in the form of round amorphous NPs that gradually grow in size, aggregate and coalesce to form crystalline mineral films similar to the structures observed in calcified human arteries. Conclusion: Our study reveals the early stages of particle formation and provides a platform to analyze the role(s) of mineralo-organic NPs in human tissues.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm.15.171

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