IFNG and IFNGR1 gene polymorphisms in children with nonresponse to the hepatitis B vaccine-Reference-Cited by-同舟云学术

IFNG and IFNGR1 gene polymorphisms in children with nonresponse to the hepatitis B vaccine

Published:2014-02 Issue:2 Volume:9 Page:123-130
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Çiftdoğan Dilek Yılmaz¹,Onay Hüseyin²,Tosun Selam³,Özdemir Taha Reşid²,Özkınay Ferda²,Vardar Fadıl¹

Affiliation:

1. Ege University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Bornova, İzmir, Turkey

2. Ege University, Department of Medical Genetics, İzmir, Turkey

3. Manisa State Hospital, Manisa, Turkey

Abstract

ABSTRACT: Aim: We investigated the +874 T/A polymorphism in the first intron of the IFNG gene and intronic (CA)n polymorphic microsatellite marker of the IFNGR 1 gene in child nonresponders to hepatitis B vaccination. Materials & methods: A total of 100 children who had anti-HBs antibody levels <10 mIU/ml after vaccination against hepatitis B were included as a nonresponder group and 100 children who had anti-HBs antibody levels >10 mIU/ml after vaccination against hepatitis B were included as a responder group. Results: The frequency of the TT genotype of the IFNG (+874 T/A) gene polymorphism was higher in nonresponders (p = 0.003). The frequencies of alleles 170 and 182 for (CA)n alleles for the intronic (CA)n microsatellite of IFNGR1 were significantly higher in nonresponders (for each, p < 0.05). Conclusion: The TT genotype of the IFNG (+874 T/A) gene, and alleles 170 and 182 for (CA)n alleles for the intronic (CA)n microsatellite of the IFNGR1 gene, may be associated with nonresponse to hepatitis B vaccination.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl.13.124

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