Hantaviruses: past, present and future

Abstract

ABSTRACT:  Hantaviruses productively infect endothelial cells in their rodent reservoirs and humans, but the infection only causes disease in humans – hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. Despite the enormous progress that has been made in understanding the pathogenesis and immune responses of hantavirus infection, there is a large gap in our molecular-based knowledge of hantaviral proteins in their structures, functions and the mechanisms that facilitate their entry, replication and assembly. Importantly, we know little about the specific viral determinants and viral protein–host interactions that drive differences noted in immune responses between the reservoir and humans. This review discusses our current understanding and future work needed for unraveling the biology of these viruses in their reservoirs and in humans.