Laxative utilization over time in chronic pain patients with opioid-induced constipation-Reference-Cited by-同舟云学术

Laxative utilization over time in chronic pain patients with opioid-induced constipation

Published:2016-11 Issue:6 Volume:6 Page:531-541
ISSN:1758-1869
Container-title:Pain Management
language:en
Short-container-title:Pain Management

Author:

Datto Catherine J¹,LoCasale Robert J²,Margolis Mary Kay³,Thompson Christine L³,Coyne Karin S³

Affiliation:

1. AstraZeneca, Wilmington, DE, USA

2. AstraZeneca, Gaithersburg, MD, USA

3. Evidera, Bethesda, MD, USA

Abstract

Aim: To determine laxative utilization over time among chronic noncancer pain patients with opioid-induced constipation (OIC). Setting: A prospective longitudinal study conducted in the USA, Canada, Germany and UK. Methods: Patients on daily opioid therapy for treatment of chronic noncancer pain with OIC were recruited from clinics to complete a survey at Baseline and weeks 2, 4, 6, 8, 12, 16, 20 and 24. Results: 489 patients completed baseline with 452 completing one or more follow-up visits. 128 (28%) were nonlaxative users, 112 (25%) were insufficient laxative users and 212 (47%) were sufficient laxative users. The consistent sufficient laxative users reported the most bowel movements per week. Conclusion: The majority of OIC patients do not take or only intermittently take laxatives.

Publisher

Future Medicine Ltd

Subject

General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pmt-2016-0010

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