Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin-Reference-Cited by-同舟云学术

Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin

Published:2018-03 Issue:4 Volume:19 Page:333-341
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Levran Orna¹,Peles Einat²³,Randesi Matthew¹,Correa da Rosa Joel⁴⁵,Shen Pei-Hong⁶,Rotrosen John⁷,Adelson Miriam²⁸,Kreek Mary Jeanne¹

Affiliation:

1. The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA

2. Dr Miriam & Sheldon G Adelson Clinic for Drug Abuse Treatment & Research, Tel Aviv Elias Sourasky Medical Center, 1 Henrietta Szold St, Tel-Aviv, 64924, Israel

3. Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel

4. Center for Clinical & Translational Science, The Rockefeller University, New York, NY 10065, USA

5. Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

6. Laboratory of Neurogenetics, National Institute on Alcohol Abuse & Alcoholism, NIH, Rockville, MD 20852, USA

7. NYU School of Medicine, New York, NY 10016, USA

8. Dr Miriam & Sheldon G Adelson Clinic for Drug Abuse Treatment & Research, Las Vegas, NV 89169, USA

Abstract

Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. Methods: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). Results: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment. Conclusion: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2017-0179

Reference54 articles.

1. Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics

2. Stress, Dysregulation of Drug Reward Pathways, and the Transition to Drug Dependence

3. Neural regulation of endocrine and autonomic stress responses

4. Stress and Addiction

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