Genetic variants associated with warfarin dosage in Kuwaiti population-Reference-Cited by-同舟云学术

Genetic variants associated with warfarin dosage in Kuwaiti population

Published:2017-06 Issue:8 Volume:18 Page:757-764
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

John Sumi Elsa¹,Antony Dinu²,Eaaswarkhanth Muthukrishnan¹,Hebbar Prashantha¹,Alkayal Fadi¹,Tuomilehto Jaakko¹,Alsmadi Osama²,Thanaraj Thangavel Alphonse¹

Affiliation:

1. Population Genomics & Genetic Epidemiology Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

2. Functional Genomics Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

Abstract

Assessing the distinct prevalence or absence of genetic variants associated with differential response to the anticoagulant medication of warfarin in different population groups is actively pursued by pharmacogenomics community. Populations from Arabian Peninsula are underrepresented in such studies. By way of examining exome- and genome-wide genotype data from 1395 Arab individuals in Kuwait, we report distinct occurrence of warfarin response-related variants rs12460590_A/CYP2A7, rs2108622_T/CYP4F2, rs2884737_C/VKORC1 and distinct absence of rs11150606_C/PRSS53 in Kuwaiti population. The presented results in conjunction with similar literature reports on Qatari population enhance the worldwide understanding on population-specific distributions of genetic variants associated with warfarin drug dosage.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2017-0020

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