Estimation and validation of acenocoumarol dosing algorithms in Bulgarian patients with cardiovascular diseases-Reference-Cited by-同舟云学术

Estimation and validation of acenocoumarol dosing algorithms in Bulgarian patients with cardiovascular diseases

Published:2015-06 Issue:3 Volume:12 Page:209-220
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Tzveova Reni¹,Dimitrova-Karamfilova Antoaneta²,Saraeva Radoslava¹,Solarova Tanya²,Naydenova Galya³,Petrova Irina²,Hristova Nataliya²,Popov Ivan¹,Nachev Gencho⁴,Mitev Vanio¹,Kaneva Radka¹

Affiliation:

1. Molecular Medicine Center, Department of Medical Chemistry & Biochemistry, Medical Faculty, Medical University – Sofia, 2 Zdrave str, Sofia 1431, Bulgaria

2. Department of Clinical Laboratory, University National Multi-profile Active Treatment Hospital “St. Ekaterina”- Sofia, 52A Pencho Slaveykov bul., Sofia 1431, Bulgaria

3. Second Department of Cardiology, University NationalMulti-profile Active Treatment Hospital „Dr. G. Stansky”- Pleven, 8A Georgi Kochev str., Pleven 5800, Bulgaria

4. Department of Cardiac Surgery, University National Multi-profile Active Treatment Hospital “St. Ekaterina”- Sofia, 52A Pencho Slaveykov bul., Sofia 1431, Bulgaria

Abstract

Aim & Methods: A total of 169 Bulgarian patients were genotyped for CYP2C9*2,*3, VKORC1-1639G>A and VKORC11173C>T. The effect of genetic and nongenetic factors on acenocoumarol dose variability was tested in a derivation cohort of patients and the obtained algorithm was validated in a test cohort. Results & Discussion: It was found that VKORC-1639G>A (25.5%), CYP2C9*2 (7.8%), CYP2C9*3 (6.1%), age (13.6%) and diagnosis (6.0%) significantly affected acenocoumarol dose variability in the derivation cohort. These factors with additional factors, such as sex (0.1%, p = 0.76), weight (2.6%, p = 0.14) and amiodarone use (3.0%, p = 0.059) accounted for 46.5% and 23.0% of the dose variability for genetic and clinical models, respectively. Conclusion: Based on the results of this investigation, validated clinical and pharmacogenetic algorithms for the prediction of a stable anticoagulant dose were developed, specifically designed for the Bulgarian population.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pme.14.80

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