Genomics in the clinic: ethical and policy challenges in clinical next-generation sequencing programs at early adopter USA institutions-Reference-Cited by-同舟云学术

Genomics in the clinic: ethical and policy challenges in clinical next-generation sequencing programs at early adopter USA institutions

Published:2015-06 Issue:3 Volume:12 Page:269-282
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Milner Lauren C¹,Garrison Nanibaa' A¹²,Cho Mildred K¹³,Altman Russ B⁴⁵⁶,Hudgins Louanne⁷,Galli Stephen J⁸⁹¹⁰,Lowe Henry J⁶,Schrijver Iris³⁸,Magnus David C¹³

Affiliation:

1. Stanford Center for Biomedical Ethics, Stanford University School of Medicine, Stanford, CA, USA

2. Center for Biomedical Ethics & Society, Departments of Pediatrics & Anthropology, Vanderbilt University Medical Center, Nashville, TN, USA

3. Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA

4. Department of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA

5. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA

6. Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

7. Division of Medical Genetics, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA

8. Stanford Center for Genomics & Personalized Medicine, Stanford University School of Medicine, Stanford, CA, USA

9. Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA

10. Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA

Abstract

Next-generation sequencing (NGS) technologies are poised to revolutionize clinical diagnosis and treatment, but raise significant ethical and policy challenges. This review examines NGS program challenges through a synthesis of published literature, website and conference presentation content, and interviews at early-adopting institutions in the USA. Institutions are proactively addressing policy challenges related to the management and technical aspects of program development. However, ethical challenges related to patient-related aspects have not been fully addressed. These complex challenges present opportunities to develop comprehensive and standardized regulations across programs. Understanding the strengths, weaknesses and current practices of evolving NGS program approaches are important considerations for institutions developing NGS services, policymakers regulating or funding NGS programs and physicians and patients considering NGS services.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pme.14.88

Reference86 articles.

1. Whole exome and whole genome sequencing

2. Diagnostic Applications of High-Throughput DNA Sequencing

3. Next-generation sequencing: ready for the clinics?

4. New Approaches to Molecular Diagnosis

5. Genohub. Active NGS Providers on Genohub. https://genohub.com.

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