PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity-Reference-Cited by-同舟云学术

PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

Published:2021-05 Issue:3 Volume:18 Page:255-267
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Mosca Alessio¹^ORCID,Del Casale Antonio²³^ORCID,Borro Marina¹⁴^ORCID,Gentile Giovanna¹⁴^ORCID,Pomes Leda Marina¹⁴,Padovano Alessio¹³,Fiaschè Federica¹³,Pinzone Vito¹³,Rapinesi Chiara¹,Zoppi Teodolinda¹³,Brugnoli Roberto¹³,Sani Gabriele⁵^ORCID,Kotzalidis Georgios Demetrios¹^ORCID,Girardi Paolo¹³^ORCID,Ferracuti Stefano⁶^ORCID,Simmaco Maurizio¹⁴,Pompili Maurizio¹³^ORCID

Affiliation:

1. Department of Neuroscience, Mental Health, & Sensory Organs (NESMOS), Faculty of Medicine & Psychology, Sapienza University, Rome, Italy

2. Department of Dynamic & Clinical Psychology, & Health Studies, Faculty of Medicine & Psychology, Sapienza University, Rome, Italy

3. Unit of Psychiatry, ‘Sant'Andrea’ University Hospital, Rome, Italy

4. Unit of Laboratory & Advanced Molecular Diagnostics, ‘Sant'Andrea’ University Hospital, Rome, Italy

5. Institute of Psychiatry & Psychology, Department of Geriatrics, Neuroscience & Orthopedics, Fondazione Policlinico Universitario IRCCS “A. Gemelli”, Università Cattolica del Sacro Cuore, Rome, Italy

6. Department of Human Neuroscience, Sapienza University; Unit of Risk Management, ‘Sant'Andrea’ University Hospital, Rome, Italy

Abstract

Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pme-2019-0141

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