Alterations in brain structure and function after chemotherapy for cancer

Abstract

The majority of cancer patients treated with chemotherapy complain of fatigue and/or cognitive dysfunction. Although many patients experience improvement shortly after completion of treatment, a substantial number of patients may continue to be symptomatic for years or even decades after their last dose of chemotherapy. This review focuses on the scope of postchemotherapy cognitive dysfunction, spotlights recent studies that investigate this problem in the short- and long-term, examines neuroimaging studies that document regional cerebral alterations observed after chemotherapy, discusses candidate mechanisms and treatments and finally comments on challenges in the field.