1. Department of Mathematics & Statistics, University of Helsinki, PO Box 68, 00014 Helsinki, Finland and Department of Mathematics, Åbo Akademi University, 20500 Åbo, Finland.
2. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland and Department of Mathematics, University of Turku, 20014 Turku, Finland
3. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland and Public Health Genomics Unit, National Institute for Health & Welfare, Helsinki, Finland and Wellcome Trust Sanger Institute, Hinxton, UK
4. Helsinki Institute for Information Technology, Aalto University, 00076 Aalto, Finland and Helsinki Institute for Information Technology, University of Helsinki, Finland