Molecular detection and phylogenetic analysis of human parechovirus in children with acute gastroenteritis in Iran-Reference-Cited by-同舟云学术

Molecular detection and phylogenetic analysis of human parechovirus in children with acute gastroenteritis in Iran

Published:2020-12 Issue:12 Volume:15 Page:783-789
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Mohammadi Mehrdad¹^ORCID,Armin Shahnaz²^ORCID,Piroozmand Ahmad³⁴^ORCID

Affiliation:

1. PhD student of Medical Bacteriology, Department of Microbiology & Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

2. Assistant Professor of Pediatric Infectious Diseases, Pediatric Infectious Research Center, Faculty of Medicine, Shaheed Behesti University of Medical Sciences, Tehran, Iran

3. Associate professor of Medical Virology, Department of Microbiology & Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

4. Autoimmune Disease Research Center, School of Medicine, Kashan University of Medical Sciences, Kasha, Iran

Abstract

Aim: Human parechovirus (HPeV) is one of the major causes of acute gastroenteritis in children. Materials & methods: Stool specimens (n = 250) were collected from children aged ≤3 years during 2018–2019. HPeV RNA was detected by reverse transcription-PCR and genotyping by VP1 gene, Rotavirus (RV) screened by ELISA. Results: HPeV was detected in 12% of the cases. The children under 6-months old (64.2%) were a sensitive group and HPeV was more prevalent during January–February (73.3%). The co-infection of HPeV with RV was 50%. All of the sequenced samples belong to the HPeV-1 genotype. Conclusion: HPeV-1 is one of the major causes of acute viral gastroenteritis in children and the co-infection of RV can be an additional infection in some cases.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2020-0114

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