Affiliation:
1. Massachusetts General Hospital, 55 Fruit Street, Bulfinch 165, Boston, MA 02114, USA.
Abstract
Paget’s disease of bone is a disorder of focal bone remodeling that occurs in the adult skeleton, and that increases in prevalence with aging. The natural history of Paget’s disease of bone is the progression of bony overgrowth and deformity, with most complications arising from these ‘…changes of shape, size and direction of the diseased bones’ (Sir James Paget 1877). There has been considerable interest in the morbidity and mortality of patients with Paget’s disease of bone, and studies addressing these issues, as well as the evaluation and treatment of Paget’s disease, will be the focus of this review. A brief review of the epidemiology and a case study will be used to illustrate specific issues arising in the evaluation and treatment of patients with Paget’s disease of bone.
Subject
Geriatrics and Gerontology,General Medicine
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