<i>NR3C1</i> gene methylation and cortisol levels in preterm and healthy full-term infants in the first 3 months of life-Reference-Cited by-同舟云学术

NR3C1 gene methylation and cortisol levels in preterm and healthy full-term infants in the first 3 months of life

Published:2022-12 Issue:24 Volume:14 Page:1545-1561
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Chalfun Georgia¹²^ORCID,Araújo Brasil Aline de¹^ORCID,Paravidino Vitor Barreto³⁴^ORCID,Soares-Lima Sheila Coelho⁵^ORCID,Souza Almeida Lopes Monique de⁵^ORCID,Santos Salú Margarida dos¹^ORCID,Barbosa E dos Santos Paulo Victor¹^ORCID,P da Cunha Trompiere Ana Carolina¹^ORCID,Vieira Milone Leo Travassos¹,Rodrigues-Santos Gustavo¹^ORCID,Genuíno de Oliveira Mariana Barros¹^ORCID,Robaina Jaqueline Rodrigues¹^ORCID,Lima-Setta Fernanda¹^ORCID,Reis Marcelo Martins¹^ORCID,Ledo Alves da Cunha Antônio José¹⁶^ORCID,Prata-Barbosa Arnaldo¹⁶^ORCID,de Magalhães-Barbosa Maria Clara¹^ORCID

Affiliation:

1. Department of Pediatrics, D’Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil

2. Department of Neonatology, Maternity School, Federal University of Rio de Janeiro (UFRJ), RJ, 22240-000, Brazil

3. Department of Epidemiology, Institute of Social Medicine, University of the State of Rio de Janeiro (UERJ), 20550-013, Brazil

4. Department of Physical Education & Sports, Naval Academy, Brazilian Navy, Rio de Janeiro, RJ, 20021-010, Brazil

5. Molecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro, RJ, 20230-130, Brazil

6. Postgraduate Program in Perinatal Health, Maternity School, Federal University of Rio de Janeiro (UFRJ), RJ, 22240-000, Brazil

Abstract

Aim: To describe NR3C1 exon-1F methylation and cortisol levels in newborns. Materials & methods: Preterm ≤1500 g and full-term infants were included. Samples were collected at birth and at days 5, 30 and 90 (or at discharge). Results: 46 preterm and 49 full-term infants were included. Methylation was stable over time in full-term infants (p = 0.3116) but decreased in preterm infants (p = 0.0241). Preterm infants had higher cortisol levels on the fifth day, while full-term infants showed increasing levels (p = 0.0177) over time. Conclusion: Hypermethylated sites in NR3C1 at birth and higher cortisol levels on day 5 suggest that prematurity, reflecting prenatal stress, affects the epigenome. Methylation decrease over time in preterm infants suggests that postnatal factors may modify the epigenome, but their role needs to be clarified.

Funder

Instituto D'Or de Pesquisa e Ensino

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2022-0444

Reference76 articles.

1. Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

2. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function

3. Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events

4. Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex

5. Early life stress and trauma: developmental neuroendocrine aspects of prolonged stress system dysregulation