Influence of antidepressant drugs on DNA methylation of ion channels genes in blood cells of psychiatric patients-Reference-Cited by-同舟云学术

Influence of antidepressant drugs on DNA methylation of ion channels genes in blood cells of psychiatric patients

Published:2022-07 Issue:14 Volume:14 Page:851-864
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Nascimento Larissa Vilela¹^ORCID,Neto Francisco Lotufo²^ORCID,Ribeiro Moreira Dalmo Antonio³^ORCID,Cerutti Virginia Braga³,Thurow Helena Strelow⁴^ORCID,Bastos Gisele Medeiros⁴^ORCID,Ferreira Eric Batista⁵^ORCID,Crespo Hirata Rosario Dominguez¹^ORCID,Hirata Mario Hiroyuki¹^ORCID

Affiliation:

1. Department of Clinical e Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil

2. Institute of Psychiatry, School of Medicine, University of Sao Paulo, Sao Paulo, 01246-903, Brazil

3. Department of Electrophysiology & Cardiac Arrhythmias, Institute Dante Pazzanese of Cardiology, Sao Paulo, 04012-909, Brazil

4. Department of Teaching & Research, Real e Benemerita Associação Portuguesa de Beneficiência, Sao Paulo, 01323-001, Brazil

5. Institute of Exact Sciences, Federal University of Alfenas, Alfenas, 37130-001, Brazil

Abstract

Aim: This study investigated the influence of antidepressant drugs on methylation status of KCNE1, KCNH2 and SCN5A promoters and ECG parameters in adult psychiatric patients. Materials & methods: Electrocardiographic evaluation (24 h) and blood samples were obtained from 34 psychiatric patients before and after 30 days of antidepressant therapy. Methylation of promoter CpG sites of KCNE1, KCNH2 and SCN5A was analyzed by pyrosequencing. Results: Three CpG and four CpG sites of KCNE1 and SCN5A, respectively, had increased % methylation after treatment. Principal component analysis showed correlations of the methylation status with electrocardiographic variables, antidepressant doses and patient age. Conclusion: Short-term treatment with antidepressant drugs increase DNA methylation in KCNE1 and SCN5A promoters, which may induce ECG alterations in psychiatric patients.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2022-0089

Reference40 articles.

1. Social Determinants of Mental Health: Where We Are and Where We Need to Go

2. Diagnosis and Pharmacotherapy of Bipolar Depression in Adults

3. Diagnosing and Treating Patients With Mixed Features

4. Treatment-Resistant Schizophrenia

5. The Cardiovascular Effects of Newer Antidepressants in Older Adults and Those With or At High Risk for Cardiovascular Diseases

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System;Molecular Biology;2024-09-11

2. Epigenetics in neurobehavioral disease;Epigenetics in Human Disease;2024