Safety levels of systemic IL-12 induced by cDNA expression as a cancer therapeutic
Author:
Affiliation:
1. Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina
2. Cancer & Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201 USA
Abstract
Funder
Intramural Research Program of the Center for Cancer Research, National Cancer Institute
Secretaria de Ciencia y Tecnología-UNC
Fundación para el Progreso de la Medicina
Publisher
Future Medicine Ltd
Subject
Oncology,Immunology,Immunology and Allergy
Link
https://www.futuremedicine.com/doi/pdf/10.2217/imt-2021-0080
Reference59 articles.
1. Interleukin 12: still a promising candidate for tumor immunotherapy?
2. New insights into IL-12-mediated tumor suppression
3. Mechanism of IL-12 mediated alterations in tumour blood vessel morphology: analysis using whole-tissue mounts
4. IL-12 Suppresses Vascular Endothelial Growth Factor Receptor 3 Expression on Tumor Vessels by Two Distinct IFN-γ–Dependent Mechanisms
5. Coexpression of IL-18 Strongly Attenuates IL-12-Induced Systemic Toxicity through a Rapid Induction of IL-10 without Affecting its Antitumor Capacity
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