Immune cells and signatures characterize tumor microenvironment and predict outcome in ovarian and endometrial cancers-Reference-Cited by-同舟云学术

Immune cells and signatures characterize tumor microenvironment and predict outcome in ovarian and endometrial cancers

Published:2021-10 Issue:14 Volume:13 Page:1179-1192
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Ni Ying¹^ORCID,Soliman Ahmed²,Joehlin-Price Amy³,Abdul-Karim Fadi³,Rose Peter G⁴,Mahdi Haider⁴⁵⁶⁷

Affiliation:

1. Department of Quantative Health Science, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA

2. Department of Pediatrics, Case Western University, 2103 Cornell Rd, Cleveland, OH 44106, USA

3. Department of Anatomic Pathology, Pathology & Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA

4. Division of Gynecologic Oncology; Obstetrics, Gynecology & Women's Health Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA

5. Translational Hematology Oncology Research Department, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA

6. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA

7. Magee Womens Research Institute, University of Pittsburgh, School of Medicine Gynecologic Oncology, University of Pittsburgh Medical Center, 300 Halket Street, Pittsburgh, PA 15213, USA

Abstract

Aims: We investigated immunogenomic signatures and correlated them with survival in ovarian cancer (OV) and endometrial cancer (EC). Materials & method: We used whole transcriptome sequencing data from uterine serous cancer and The Cancer Genome Atlas data of OV and EC (n = 719). Gene expression score was calculated. Population abundance of immune cells were estimated. Results: TGF-β, myeloid cells, IFN-γ, T cells, B cells and endothelial cells predicted overall survival. Whereas CD47, neutrophils and endothelial cells predicted progression-free survival. In multivariate analyses, TGF-β, CD47 and monocytic cells predicted survival in high levels of microsatellite instability (MSI-H) EC whereas high IFN-γ trended toward improved survival in the MSI-S EC. High IFN-γ/low TGF-β and high IFN-γ/low CD47 signatures predicted longer overall survival. Low TGF-β/low CD47 signature predicted longer overall survival only in the MSI-H EC. Conclusion: Our data support the role of immune markers in predicting survival in OV/EC.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt-2021-0052

Reference30 articles.

1. A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients

2. Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy

3. Macrophage Polarization in the Development and Progression of Ovarian Cancers: An Overview

4. TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

5. TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

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