miRNA profiles change during grass pollen immunotherapy irrespective of clinical outcome-Reference-Cited by-同舟云学术

miRNA profiles change during grass pollen immunotherapy irrespective of clinical outcome

Published:2022-04 Issue:6 Volume:14 Page:433-444
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Specjalski Krzysztof¹^ORCID,Maciejewska Agnieszka²,Romantowski Jan¹^ORCID,Pawłowski Ryszard²^ORCID,Jassem Ewa³^ORCID,Niedoszytko Marek¹^ORCID

Affiliation:

1. Department of Allergology, Medical University of Gdansk, ul. Smoluchowskiego 17, Gdansk, 80-952, Poland

2. Laboratory of Forensic Genetics, Department of Forensic Medicine, Medical University of Gdansk, ul. Debowa 23, Gdansk, 80-208, Poland

3. Department of Pneumonology, Medical University of Gdansk, ul. Smoluchowskiego 17, Gdansk, 80-952, Poland

Abstract

Background: Subcutaneous immunotherapy (SCIT) is widely used in the treatment of allergic rhinitis (AR). This study aimed to determine the expression of 48 miRNAs in patients with AR undergoing grass pollen SCIT and investigate relations with clinical outcomes. Methodology: Expression of selected miRNAs was determined using RT-PCR in the full blood of 16 patients with AR and seven healthy controls. Results: miR-136, miR-208 and miR-190 were upregulated in the AR group. After 6 months of SCIT, significant downregulation of some proinflammatory miRNAs and upregulation of several miRNAs regulating Th1/Th2 balance were found. No differences were found between good and poor responders. Conclusion: miRNAs may play a regulatory role in SCIT, leading to tolerance induction.

Funder

Gdański Uniwersytet Medyczny

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt-2021-0217

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