Affiliation:
1. Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2. Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Abstract
Background: This study investigates the therapeutic and protective effects of Tregs, myeloid-derived suppressor cells (MDSCs) and IL-2 on multiple sclerosis (MS) disease model. Materials & methods: C57BL/6 mice were immunized to develop an experimental autoimmune encephalomyelitis (EAE) model. We then investigated effects of pre- and post-treatment EAE mice with Tregs, MDSCs and IL-2 on inflammation and demyelination in brain tissue, and on the number of Treg, granulocytic-MDSC and Th-17 cells in spleen. Results: Pre- and post-treatment of EAE mice by Tregs, MDSCs and IL-2 resulted in no weight change, reduced Th-17 cells and suppression of pathological properties. Conclusion: Pre- and post-treatment of immunized mice by Tregs, MDSCs and IL-2 prevent EAE induction.
Funder
Golestan University of Medical Sciences
Subject
Oncology,Immunology,Immunology and Allergy
Cited by
8 articles.
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