Tacrolimus dose requirement in pediatric liver transplantation: influence of CYP3A5 gene polymorphism-Reference-Cited by-同舟云学术

Tacrolimus dose requirement in pediatric liver transplantation: influence of CYP3A5 gene polymorphism

Published:2013-07 Issue:9 Volume:14 Page:1017-1025
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Durand Philippe¹,Debray Dominique²,Kolaci Mikaela³,Bouligand Jerome⁴,Furlan Valérie⁵,Fabre Monique⁶,Letierce Alexia⁷,Verstuyft Céline³,Becquemont Laurent⁸

Affiliation:

1. Pediatric Intensive Care Department, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France

2. Pediatric Hepatology Department, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France

3. Pharmacology Department, University Paris-Sud, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France

4. Molecular Genetics, Pharmacogenetics & Hormonology Department, University Paris-Sud, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France

5. Pharmacy Department, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France

6. Pathology Department, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France and Pathology Department, Institute of Cancer Gustave Roussy, Villejuif, France

7. Clinical Research Unit (URC) Paris Sud, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France

8. Pharmacology Department, University Paris-Sud, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France and Clinical Research Unit (URC) Paris Sud, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, France and Clinical Research Center (CRC) Paris Sud, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, le Kremlin Bicêtre, 78, rue du Général Leclerc, Cedex, France.

Abstract

Aim: Little information is available regarding the influence of CYP3A5 genetic polymorphisms on tacrolimus dose requirement in pediatric liver transplantation. Patients & methods: We performed a retrospective study among 179 pediatric liver recipients grafted between 2002 and 2009 in order to determine the influence of donor CYP3A5 genotype along with clinical variables on tacrolimus daily dose requirement during the first weeks following transplantation. Results: Mean stable tacrolimus daily dose requirement was higher among children who received a liver expressing CYP3A5 (carrying the CYPA3A5*1 allele) compared with those with a liver that did not express CYP3A5 (CYP3A5*3/*3 genotype): 0.29 ± 0.20 vs 0.18 ± 0.13 mg.kg-1.d-1, p = 0.005, respectively. A younger recipient age and fluconazole prescription were also significantly associated with tacrolimus daily dose requirement. Time to reach stable tacrolimus therapeutic trough concentrations was prolonged among patients with a CYP3A5-expressing graft (26 vs 21 days, p = 0.04). Conclusion: Donor CYP3A5 genotype partially explains tacrolimus dose requirement. Original submitted 30 January 2013; Revision submitted 2 May 2013

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs.13.87

Reference31 articles.

1. Long-term outcome of pediatric liver transplantation for biliary atresia: A 10-year follow-up in a single center

2. Safety and efficacy of tacrolimus in pediatric liver recipients

3. Tacrolimus and steroids versus ciclosporin microemulsion, steroids, and azathioprine in children undergoing liver transplantation: randomised European multicentre trial

4. Association of the Multidrug Resistance-1 Gene Single-Nucleotide Polymorphisms with the Tacrolimus Dose Requirements in Renal Transplant Recipients

5. Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Leveraging clinical decision support to reduce the risk of discordant pharmacogenomics results;Pharmacogenomics;2022-12

2. Strong influence of donor and recipient CYP3A5 genotype on tacrolimus disposition leading to difficult dose adjustment in a pediatric liver transplantation;Journal of Liver Transplantation;2022-10

3. Compare the performance of multiple machine learning models in predicting tacrolimus concentration for infant patients with living donor liver transplantation;Pediatric Transplantation;2022-08-30

4. Multiple microRNAs regulate tacrolimus metabolism through CYP3A5;Pharmacological Research;2021-02

5. Bacterial infections in children after liver transplantation: A single‐center surveillance study of 345 consecutive transplantations;Transplant Infectious Disease;2019-12-09