Candidate gene analysis of asthma in a population of Arab descent: a case–control study in Jordan-Reference-Cited by-同舟云学术

Candidate gene analysis of asthma in a population of Arab descent: a case–control study in Jordan

Published:2017-01 Issue:1 Volume:14 Page:51-61
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Almomani Basima A¹,Al-Eitan Laith N²³,Samrah Shaher M⁴⁵,Al-Quasmi Mohammed N⁶,McKnight Amy J⁷

Affiliation:

1. Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science & Technology, Irbid, Jordan

2. Department of Applied Biological Sciences, Jordan University of Science & Technology, Irbid, Jordan

3. Department of Biotechnology & Genetic Engineering, Jordan University of Science & Technology, Irbid, Jordan

4. Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan

5. Department of Internal Medicine, King Abdullah University Hospital, Irbid, Jordan

6. Department of Medical Laboratory, King Abdullah University Hospital, Irbid, Jordan

7. Centre for Public Health, Queen's University of Belfast, Northern Ireland, UK

Abstract

Aim: To evaluate whether SNPs (n = 15) in ten candidate genes (ADRB2, ADH5, ARGI, CRHR1, STIP1, LTA4H, LTC4S, ALOX5, ABCC1 and OATP2B1) are associated with asthma in Jordanian population of Arab descent. Methods: A case–control study included 245 adult asthmatics and 249 controls. Results: Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma (p < 0.001). The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls. The rs1141370 SNP (Val34Met) in ADRB2 is not polymorphic in our cohort. Conclusion: The rs2236647 SNP could act as a reliable tool to identify individuals at risk of developing asthma and provision of early intervention in population of Arab descent.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pme-2016-0059

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