Targeting safety in the clinic for precise genome editing using CRISPR: a genotoxicologist's perspective
Author:
Affiliation:
1. AstraZeneca Innovative Medicines & Early Development Darwin Building 310, Milton Science Park, Cambridge, CB4 OWG, UK
Publisher
Future Medicine Ltd
Subject
Pharmacology,Molecular Medicine,General Medicine
Link
https://www.futuremedicine.com/doi/pdf/10.2217/pme-2016-0026
Reference17 articles.
1. Clinical Applications of Gene Therapy for Primary Immunodeficiencies
2. The new frontier of genome engineering with CRISPR-Cas9
3. An International Summit on Human Gene Editing, Washington, D.C. December 1–3, 2015. National Academy of Sciences. https://innovativegenomics.org/international-summit-on-human-gene-editing/.
4. Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
5. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
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