Cytochrome P450 gene-based drug prescribing and factors impacting translation into routine clinical practice-Reference-Cited by-同舟云学术

Cytochrome P450 gene-based drug prescribing and factors impacting translation into routine clinical practice

Published:2005-08 Issue:3 Volume:2 Page:213-224
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Wilke Russell A¹,Musana A Kenneth²,Weber Wendell W³

Affiliation:

1. Center for Human Genetics, Marshfield Clinic Research Foundation, Department of Internal Medicine, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA.

2. Department of Internal Medicine, Marshfield Clinic, Marshfield, WI, USA

3. Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA

Abstract

Pharmacogenetics represents a rapidly advancing, competitive field of investigation. Due to the potential for clinically recognizable interactions between a set of old polymorphic genes and a relatively new environmental insult (drugs), many human geneticists believe that variability in the drug-metabolizing enzyme systems will soon translate into clinical practice across entire populations. Despite this, the field has not yet received widespread clinical acceptance. This article will review the common cytochrome P450 gene polymorphisms and discuss the factors that may facilitate (or attenuate) their translation into clinical practice.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/17410541.2.3.213

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