Programmed death-1 & its ligands: promising targets for cancer immunotherapy

Author:

Shrimali Rajeev K1,Janik John E1,Abu-Eid Rasha1,Mkrtichyan Mikayel1,Khleif Samir N1

Affiliation:

1. Georgia Regents University Cancer Center, Augusta, GA 30912, USA

Abstract

Novel strategies for cancer treatment involving blockade of immune inhibitors have shown significant progress toward understanding the molecular mechanism of tumor immune evasion. The preclinical findings and clinical responses associated with programmed death-1 (PD-1) and PD-ligand pathway blockade seem promising, making these targets highly sought for cancer immunotherapy. In fact, the anti-PD-1 antibodies, pembrolizumab and nivolumab, were recently approved by the US FDA for the treatment of unresectable and metastatic melanoma resistant to anticytotoxic T-lymphocyte antigen-4 antibody (ipilimumab) and BRAF inhibitor. Here, we discuss strategies of combining PD-1/PD-ligand interaction inhibitors with other immune checkpoint modulators and standard-of-care therapy to break immune tolerance and induce a potent antitumor activity, which is currently a research area of key scientific pursuit.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

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