Preventing stem cell transplantation-associated viral infections using T-cell therapy

Author:

Tzannou Ifigeneia1,Leen Ann M1

Affiliation:

1. Center for Cell & Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital & Texas Children's Hospital, 1102 Bates Street, Suite 1770, Houston, TX 77030, USA

Abstract

Hematopoietic stem cell transplantation is the treatment of choice for many hematologic malignancies and genetic diseases. However, viral infections continue to account for substantial post-transplant morbidity and mortality. While antiviral drugs are available against some viruses, they are associated with significant side effects and are frequently ineffective. This review focuses on the immunotherapeutic strategies that have been used to prevent and treat infections over the past 20 years and outlines different refinements that have been introduced with the goal of moving this therapy beyond specialized academic centers.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

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