Combined response of advanced cutaneous squamous cell carcinoma and renal cell carcinoma to immunotherapy: a case report-Reference-Cited by-同舟云学术

Combined response of advanced cutaneous squamous cell carcinoma and renal cell carcinoma to immunotherapy: a case report

Published:2022-12 Issue:18 Volume:14 Page:1419-1427
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Murianni Veronica¹^ORCID,Cerbone Luigi²^ORCID,Rescigno Pasquale³^ORCID,Catalano Fabio¹^ORCID,Damassi Alessandra¹^ORCID,Cremante Malvina¹^ORCID,Gandini Annalice¹^ORCID,Puglisi Silvia¹^ORCID,Pesola Guido⁴^ORCID,Banna Giuseppe Luigi⁵^ORCID,Buti Sebastiano⁶⁷^ORCID,Signori Alessio⁸^ORCID,Fornarini Giuseppe¹^ORCID,Rebuzzi Sara Elena⁹¹⁰^ORCID

Affiliation:

1. Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132, Genova, Italy

2. Mesothelioma & Rare Cancer Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121, Alessandria, Italy

3. Candiolo Cancer Institute, FPO-IRCCS, 10060, Candiolo, Turin, Italy

4. Clinic of Medical Oncology, Oncology Institute of Southern Switzerland, 6500, Bellinzona, Switzerland

5. Department of Oncology, Portsmouth Hospitals University NHS Trust, SO16 6YD, Portsmouth, UK

6. Medical Oncology Unit, University Hospital of Parma, 43126, Parma, Italy

7. Department of Medicine & Surgery, University of Parma, 43126, Parma, Italy

8. Department of Health Sciences (DISSAL), University of Genova, 16132, Genova, Italy

9. Medical Oncology Unit, Ospedale San Paolo, 17100, Savona, Italy

10. Department of Internal Medicine & Medical Specialties (Di.M.I.), University of Genova, 16132, Genova, Italy

Abstract

Immune checkpoint inhibitors have significantly improved the therapeutic scenario of many different advanced malignancies and could be an effective treatment strategy in synchronous or metachronous tumors. The authors describe the clinical case of a patient who experienced a long-lasting response of his metastatic renal cell carcinoma and an optimal response of his locally advanced cutaneous squamous cell carcinoma to immunotherapy. The systemic treatment was chosen based on a literature review of several clinical reports, since there was no prospective study on anti-PD-1 blockade activity in cutaneous squamous cell carcinoma when the patient started the treatment. This clinical case supports the growing evidence for immunotherapy as a valid treatment option across different types of advanced tumors.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt-2022-0150

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