Establishment of humanized mice and its application progress in cancer immunotherapy-Reference-Cited by-同舟云学术

Establishment of humanized mice and its application progress in cancer immunotherapy

Published:2023-06 Issue:9 Volume:15 Page:679-697
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Ding Tianlong¹²^ORCID,Yu Yang¹,Pan Xiaoyuan³,Chen Hao²⁴^ORCID

Affiliation:

1. The Second Clinical Medical College, Lanzhou University, Lanzhou, 730030, PR China

2. Department of Tumor Surgery, Lanzhou University Second Hospital, Lanzhou, 730030, PR China

3. Department of Vision Rehabilitation, Gansu Province Hospital Rehabilitation Center, Lanzhou, 730030, PR China

4. Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou, 730030, PR China

Abstract

The current high prevalence of malignant tumors has attracted considerable attention, and treating advanced malignancies is becoming increasingly difficult. Although immunotherapy is a hopeful alternative, it is effective in only a few people. Thus, development of preclinical animal models is needed. Humanized xenotransplantation mouse models can help with selecting treatment protocols, evaluating curative effects and assessing prognosis. This review discusses the establishment of humanized mouse models and their application prospects in cancer immunotherapy to identify tailored therapies for individual patients.

Funder

Cuiying Technology Innovation Project of the Second Hospital of Lanzhou University

Lanzhou Science and Technology Bureau New Coronary Pneumonia Prevention and Control Technology Research Project

Lanzhou Chengguan District Science and Technology Plan Project

Gansu Province Science and Technology Major Special International Science and Technology Cooperation Project

Key Talent Projects in Gansu Province

National Natural Science Foundation of China

Horizontal issues

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy