Antifungal activity of β-lapachone against azole-resistant Candida spp. and its aspects upon biofilm formation-Reference-Cited by-同舟云学术

Antifungal activity of β-lapachone against azole-resistant Candida spp. and its aspects upon biofilm formation

Published:2020-11 Issue:16 Volume:15 Page:1543-1554
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

da Silva Cecília R¹²^ORCID,S Campos Rosana de¹³,de A Neto João B¹³,Sampaio Letícia S¹²,do Nascimento Francisca BSA¹²,do AV Sá Lívia G¹²,Cândido Thiago M¹²,Magalhães Hemerson IF⁴,da Cruz Eduardo HG⁵,da Silva Júnior Eufrânio N⁵,de Moraes Manoel O⁶,Cavalcanti Bruno C⁶,Silva Jacilene⁷,Marinho Emmanuel S⁷,Júnior Hélio VN¹²

Affiliation:

1. Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil

2. Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE 60430-170, Brazil

3. Christus University Center (UNICHRISTUS), Fortaleza, CE 60160-230, Brazil

4. School of Pharmacy, Federal University of Paraíba, João Pessoa 58059-900, PB, Brazil

5. Laboratory of Synthetic & Heterocyclic Chemistry, Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Minas Gerais 31270-901, Brazil

6. Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil

7. Departmentof Chemistry, Group of Theoretical Chemistry and Electrochemistry (GQTE), StateUniversity of Ceará, Limoeiro do Norte, Ceará 62930-000, Brazil

Abstract

Aim: The purpose of this study was to assess the antifungal effect of β-lapachone (β-lap) on azole-resistant strains of Candida spp. in both planktonic and biofilm form. Materials & methods: The antifungal activity of β-lap was evaluated by broth microdilution, flow cytometry and the comet assay. The cell viability of the biofilms was assessed using the MTT assay. Results: β-lap showed antifungal activity against resistant strains of Candida spp. in planktonic form. In addition, β-lap decreased the viability of mature biofilms and inhibited the formation of biofilms in vitro. Conclusion: β-lap showed antifungal activity against Candida spp., suggesting that the compound can be utilized as an adjunct agent in the treatment of candidiasis.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0011

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