Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon-Reference-Cited by-同舟云学术

Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon

Published:2020-11 Issue:16 Volume:15 Page:1555-1569
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Rafei Rayane¹^ORCID,Hawli Malaik¹,Osman Marwan¹^ORCID,Khelissa Simon²^ORCID,Salloum Tamara³^ORCID,Dabboussi Fouad¹^ORCID,Tokajian Sima³^ORCID,Hamze Monzer¹^ORCID

Affiliation:

1. Laboratoire Microbiologie Santé et Environnement (LMSE), Doctoral School for Science & Technology, Faculty of Public Health, Lebanese University, Tripoli, 1300, Lebanon

2. Université de Lille, Centre National de la Recherche Scientifique, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Centrale Lille, Unité Mixte de Recherche 8207 – Unité Matériaux et Transformations, Lille, 59000, France

3. Department of Natural Sciences, School of Arts & Sciences, Lebanese American University, Byblos campus, Postal Box 36, Byblos, 1401, Lebanon

Abstract

Aim: To characterize the epidemiology of group A Streptococcus (GAS) involved in nonpharyngeal infections sparingly addressed in Lebanon. Materials & methods: A collection of 63 nonpharyngeal GAS isolates recovered between 2010 and 2019 from northern Lebanon were analyzed through emm typing, virulence gene profiling, FCT typing and antibiotic susceptibility analysis. Results & conclusion: A total of 29 emm subtypes was detected, with emm1 being the most dominant. A great intraclonal divergence driven by the loss and gain of superantigens or by the structural variability within the FCT regions was unraveled. The resistance rates for erythromycin and tetracycline were 8 and 20.6%, respectively. The 30-valent vaccine coverage was 76%. This study evidences the complexity of the neglected GAS pathogen in Lebanon.

Funder

Université Libanaise

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0072

Reference47 articles.

1. Decline in macrolide resistance rates among Streptococcus pyogenes causing pharyngitis in children isolated in Italy

2. Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

3. High virulence gene diversity in Streptococcus pyogenes isolated in Central Italy

4. Population Genetics and Linkage Analysis of Loci within the FCT Region of Streptococcus pyogenes

5. Macrolide-resistantStreptococcus pyogenes: prevalence and treatment strategies

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A global snapshot on the prevalent macrolide-resistant emm types of Group A Streptococcus worldwide, their phenotypes and their resistance marker genotypes during the last two decades: A systematic review;Infection, Genetics and Evolution;2022-04

2. Molecular Characterization of Antimicrobial Resistance and Virulence Genes of Bacterial Pathogens from Bovine and Caprine Mastitis in Northern Lebanon;Microorganisms;2021-05-27