(-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp.-Reference-Cited by-同舟云学术

(-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp.

Published:2020-11 Issue:16 Volume:15 Page:1527-1534
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

de Freitas Beatriz C¹^ORCID,Queiroz Paula A¹^ORCID,Baldin Vanessa P¹^ORCID,do Amaral Pedro HR²^ORCID,Rodrigues Lucas LF³^ORCID,Vandresen Fabio³^ORCID,R Caleffi-Ferracioli Katiany¹²^ORCID,de L Scodro Regiane B²⁴^ORCID,Cardoso Rosilene F¹²⁴^ORCID,Siqueira Vera LD¹²^ORCID

Affiliation:

1. Postgraduate Program in Bioscience & Physiopathology, State University of Maringa, Parana 87020 900, Brazil

2. Department of Clinical Analysis & Biomedicine, Laboratory of Medical Bacteriology, State University of Maringa, Parana 87020 900, Brazil

3. Department of Chemistry, Federal Technological University of Parana, Londrina, Parana 86036 370, Brazil

4. Postgraduate Program in Health Sciences, State University of Maringa, Parana 87020 900, Brazil

Abstract

Aim: To evaluate the activity of (-)-camphene-based thiosemicarbazide (TSC) and 4-hydroxy-thiosemicarbazone (4-OH-TSZ), alone and in combination against Gram-positive. Material & methods: MIC were determined for Staphylococcus aureus, Enterococcus spp. reference strains and clinical isolates. Drug combination, time–kill and cytotoxicity assays were also performed. Results: TSC and 4-OH-TSZ demonstrated potent inhibitory activity against S. aureus and Enterococcus spp., including multidrug-resistant isolates (MIC ranging from 1.9 to 31.2 μg/ml), and were bactericidal for the reference strains of both Gram-positive tested. The derivatives proved to be selective for the bacteria and synergistic with oxacillin and vancomycin. Conclusion: (-)-Camphene-based derivatives can represent promising drug candidates against critical pathogens, such as S. aureus and Enterococcus spp., including MRSA and vancomycin resistance Enterococcus spp. isolates.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0131

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