Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV-Reference-Cited by-同舟云学术

Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV

Published:2020-11 Issue:17 Volume:15 Page:1645-1652
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Zhang Keming¹²^ORCID,Li Hang¹²,Zhang Lei¹²,Liao Wanqing¹²,Ling Liyan³,Li Xiaojing⁴,Lin Jianjun⁵,Xu Bin⁶,Pan Weihua¹²,Zhang Qilong⁶⁷

Affiliation:

1. Shanghai Key Laboratory of Molecμlar Medical Mycology, Shanghai Institute of Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, PR China

2. Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, PR China

3. Department of Laboratory Medicine, Pinghu Second People's Hospital, Zhejiang, 314200, PR China

4. Department of Dermatology, Affiliated Hospital of Hebei University of Engineering, Hebei, 430000, PR China

5. Department of Clinical Laboratory, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang, 315000, PR China

6. Department of Neurology, Jiangxi Chest Hospital, Jiangxi, 330000, PR China

7. Department of Neurology, Jiangxi Provincial people’s Hospital, Jiangxi, 330000, PR China

Abstract

Aim: To evaluate the clinical data and quantitative cerebrospinal fluid for associations with the outcome of cryptococcal meningitis (CM) patients in the hospital. Patients & methods: We retrospectively analyzed a total of 139 CM patients comprising 108 without HIV and 31 with HIV admitted in a Jiang Xi hospital. Resμlts: We found that CM patients with the high fungal burden (≥10 yeasts/μl) (26.3%) had a worse prognosis than those with the low fungal burden (<10 yeasts/μl). (4.9%) (p = 0.0007 <0.05). Conclusion: In CM patients, a fungal burden of 10 yeasts/μl in the first cerebrospinal fluid test may be used as an indicator of patient prognosis, and we can personalize patients’ treatment based on the fungal burden to improve prognosis.

Funder

Shanghai Municipal Commission of Health and Family Planning

Chinese Academy of Engineering

The Shanghai Sailing Program

National Natural Science Foundation of China

The Major National R&D Projects of the National Health Department

Science and Technology Commission of Shanghai Municipality

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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