Rescue of streptomycin activity by piperine in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Rescue of streptomycin activity by piperine in Mycobacterium tuberculosis

Published:2021-06 Issue:9 Volume:16 Page:623-633
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Calsavara Leonora L¹²^ORCID,Hegeto Laíse A³²^ORCID,Sampiron Eloisa G³²^ORCID,Costacurta Giovana F³²^ORCID,Murase Letícia S³²^ORCID,Souza João VP¹²^ORCID,de Almeida Aryadne L¹²^ORCID,de S Santos Nathally C¹²^ORCID,Siqueira Vera LD¹²^ORCID,de L Scodro Regiane B³²^ORCID,Cardoso Rosilene F¹³²^ORCID,Caleffi-Ferracioli Katiany R¹²^ORCID

Affiliation:

1. Postgraduate Program in Bioscience & Physiopathology, State University of Maringá (UEM), Maringá, Paraná, Brazil

2. Department of Clinical Analysis & Biomedicine, Laboratory of Medical Bacteriology, State University of Maringa, Parana, Brazil

3. Postgraduate Program in Health Sciences, State University of Maringá (UEM), Maringá, Paraná, Brazil

Abstract

Aim: To evaluate the modulatory effect of piperine (PIP) on streptomycin (SM) activity in Mycobacterium tuberculosis ( Mtb). Materials & methods: SM and PIP minimum inhibitory concentration (MIC) and combinatory activity were determined in Mtb H37Rv and in susceptible and resistant clinical isolates. Ethidium bromide accumulation assay and relative quantification of efflux pumps genes ( rv1258c, rv1218c and rv2942), after SM and SM+PIP combination exposure, were also performed. Results: PIP concentration of 25 μg/ml (1/4× MIC) was able to inhibit efflux pumps activity, to modulate SM activity in Mtb, and conducted changes in the relative quantification of efflux pumps genes. Conclusion: SM+PIP combination was able to rescue the SM-susceptible MIC values in SM-resistant Mtb.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0124

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