Evaluation of the immunoprotective effects of IF-2 GTPase and SSU05-1022 as a candidate for a Streptococcus suis subunit vaccine-Reference-Cited by-同舟云学术

Evaluation of the immunoprotective effects of IF-2 GTPase and SSU05-1022 as a candidate for a Streptococcus suis subunit vaccine

Published:2021-07 Issue:10 Volume:16 Page:721-729
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Chen Tumei¹,Wang Chenchen¹,Hu Linlin¹,Lu Hao¹,Song Fangyu¹,Zhang Anding¹²³⁴,Wang Xiangru¹²³⁴^ORCID,Chen Huanchun¹²³⁴,Tan Chen¹²³⁴

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, China

2. Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei, 430070, China

3. Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of The People’s Republic of China, Wuhan, Hubei, 430070, China

4. International Research Center for Animal Disease, Ministry of Science & Technology of The People’s Republic of China, Wuhan, Hubei, 430070, China

Abstract

Aim: This study aims to develop a subunit vaccine with high cross-protection for Streptococcus suis. Materials & methods: Four-week-old female BALB/c mice were first immunized with a single and mixed protein. Various indicators, such as antibody titers and various cytokine levels, were further analyzed. Results: The results showed that purified recombinant proteins IF-2 and 1022 had a good protective effect against lethal doses of S. suis serotype 2 and S. suis serotype 9. This study showed immunization with recombinant proteins. Conclusion: IF-2 and 1022 can enhance cross-protection against S. suis serotypes 2 and 9.

Funder

The National Key R&D Program of China,

The emarked fund for China Agriculture Research System,

The Outstanding youth project of Natural Science Foundation in Hubei Province,

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0232

Reference32 articles.

1. The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions