miRNA-15a/16: as tumor suppressors and more-Reference-Cited by-同舟云学术

miRNA-15a/16: as tumor suppressors and more

Published:2015-08 Issue:16 Volume:11 Page:2351-2363
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Huang Enyu¹,Liu Ronghua¹,Chu Yiwei¹²

Affiliation:

1. Department of Immunology, Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, People's Republic of China

2. Biotherapy Research Center, Fudan University, Shanghai 200032, People's Republic of China

Abstract

Since their first discovery in chronic lymphocytic leukemia, miR-15a and miR-16 have been reported to act as tumor suppressors or potential oncomiRs in different types of cancer. This review summarizes the history, biological properties and the important functions of these two miRNAs in cancer. It also introduces their roles as regulators of immune responses and angiogenesis, endogenous controls as well as potential targets and hallmarks of cancer.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon.15.101

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