Hedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas-Reference-Cited by-同舟云学术

Hedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas

Published:2015-11 Issue:22 Volume:11 Page:2997-3002
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Piérard-Franchimont Claudine¹²,Hermanns-Lê Trinh²,Paquet Philippe²,Herfs Michael³,Delvenne Philippe²³⁴,Piérard Gérald E¹

Affiliation:

1. Laboratory of Skin Bioengineering & Imaging (LABIC), Department of Clinical Sciences, University of Liège, Belgium

2. Department of Dermatopathology, Unilab Lg, Liège University Hospital, Liège, Belgium

3. Laboratory of Experimental Pathology, Liège University Hospital, Liège, Belgium

4. Departments of Pathology, Unilab Lg, Liège University Hospital, Liège, Belgium

Abstract

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in PTCH1 or smoothened, two conducting proteins of the Hedgehog pathway. They rarely progress deeply and metastasize; however, if they do, these advanced basal cell carcinoma become amenable to treatment by inhibiting the Hedgehog and the P13K–mTOR pathways. Such innovative drugs include vismodegib, cyclopamine, itraconazole, everolimus and a few other agents that are in early clinical development.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon.15.181

Reference20 articles.

1. Basal cell carcinomas: molecular abnormalities and molecularly targeted therapies

2. Basal cell carcinoma: a paradigm for targeted therapies

3. Emerging Treatments and Signaling Pathway Inhibitors

4. Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inhibition of the Sonic Hedgehog Pathway using Small Molecule Inhibitors: Targeting Colon Cancer Stem Cells;Current Cancer Therapy Reviews;2023-05

2. Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis;Frontiers in Pharmacology;2022-02-15

3. Recent Updates on the Involvement of PI3K/AKT/mTOR Molecular Cascade in the Pathogenesis of Hyperproliferative Skin Disorders;Frontiers in Medicine;2021-04-30

4. Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma;Journal of Clinical Medicine;2020-09-18

5. miR‐18a expression in basal cell carcinoma and regulatory mechanism on autophagy through mTOR pathway;Clinical and Experimental Dermatology;2020-08-04