KRT 15 as a prognostic biomarker is highly expressed in esophageal carcinoma-Reference-Cited by-同舟云学术

KRT 15 as a prognostic biomarker is highly expressed in esophageal carcinoma

Published:2020-09 Issue:25 Volume:16 Page:1903-1909
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Lin Jian-bo¹,Feng Zhi¹,Qiu Ming-lian¹,Luo Rong-gang¹,Li Xu¹^ORCID,Liu Bo¹

Affiliation:

1. Thoracic Surgery Department, First Affiliated Hospital, Fujian Medical University, Chazhong Road 20#, Fuzhou City, 350005, PR China

Abstract

Aim: To investigate the expression and prognostic value of KRT 15 in esophageal carcinoma. Materials & methods: The expression levels of KRT 15 were measured in 128 cases of esophageal carcinoma and matched adjacent normal tissues by immunohistochemistry and Western blot assays. Results & conclusion: Western blot analysis shown the expression levels of KRT 15 in esophageal carcinoma were significantly higher compared with those in matched adjacent normal tissues (p < 0.001). immunohistochemistry result shown the high-expression rate of KRT 15 in esophageal carcinoma were 56.3%, which was significantly higher than those in normal tissues (35.9%; p = 0.002). KRT 15 high-expression correlated with T stage, lymph node metastasis, tumor node metastasis stage and prognosis (p < 0.05). These data indicate KRT 15 as a prognostic biomarker is highly expressed in esophageal carcinoma.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2019-0603

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