DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes-Reference-Cited by-同舟云学术

DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

Published:2021-06 Issue:11 Volume:13 Page:845-858
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Garcia-Ruiz Beatriz¹²³^ORCID,de Moura Manuel Castro⁴^ORCID,Muntané Gerard¹²³⁵⁶^ORCID,Martorell Lourdes¹²³⁵^ORCID,Bosch Elena⁶^ORCID,Esteller Manel⁴⁷⁸⁹^ORCID,J Canales-Rodríguez Erick⁵¹⁰¹¹^ORCID,Pomarol-Clotet Edith⁵¹⁰^ORCID,Jiménez Esther⁵¹²^ORCID,Vieta Eduard⁵¹²^ORCID,Vilella Elisabet¹²³⁵^ORCID

Affiliation:

1. Hospital Universitari Institut Pere Mata, Ctra. de l’Institut Pere Mata, s/n. 43206, Reus, Catalonia, Spain

2. Institut d'Investigació Sanitària Pere Visgili (IISPV), C/ Dr. Mallafrè Guasch, 4 Edifici modular Hospital Universitari de Tarragona Joan XXIII. 43007, Tarragona, Catalonia, Spain

3. Universitat Rovira i Virgili (URV), Facultat de Medicina i Ciències de la Salut, Departament de Psiquiatria, C/Sant Llorenç, 21. 43201, Reus, Catalonia, Spain

4. Josep Carreras Leukaemia Research Institute (IJC), Josep Carreras Building, Ctra de Can Ruti, Camí de les Escoles, 08916, Badalona, Barcelona, Catalonia, Spain

5. Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), C/Melchor Fernández Almagro, 3. 28029, Madrid, Spain

6. Departament de Ciències Experimentals i de la Salut, Institut de Biologia Evolutiva (UPF-CSIC), Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona (PRBB), C/Dr. Aiguader, 88, 08003, Barcelona, Catalonia, Spain

7. Centro de Investigación Biomédica en Red Cáncer (CIBERONC), C/Melchor Fernández Almagro, 3. 28029, Madrid, Spain

8. Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig de Lluís Companys, 23. 08010, Barcelona, Catalonia, Spain

9. Physiological Sciences Department, School of Medicine & Health Sciences, University of Barcelona (UB), Feixa Llarga, 08907, l'Hospitalet de Llobregat, Barcelona, Catalonia, Spain

10. FIDMAG Research Foundation, Germanes Hospitalàries, Av. Jordà, 8. 08035, Barcelona, Catalonia, Spain

11. Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), Station 11. CH-1015, Lausanne, Switzerland

12. Bipolar & Depressive Disorders Unit, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, Villarroel, 170, 12-0. 08036, Barcelona, Catalonia, Spain

Abstract

Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.

Funder

Brain and Behavior Research Foundation

Instituto de Salud Carlos III

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2021-0006

Reference57 articles.

1. Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

2. Structural Abnormalities in Bipolar Euthymia: A Multicontrast Molecular Diffusion Imaging Study