Development and validation of a ferroptosis-related model for three digestive tract tumors based on a pan-cancer analysis-Reference-Cited by-同舟云学术

Development and validation of a ferroptosis-related model for three digestive tract tumors based on a pan-cancer analysis

Published:2021-09 Issue:18 Volume:13 Page:1497-1514
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Zhang Zhongjing¹,Papa Akuetteh Percy David²^ORCID,Lin Leilei³,Wu Yiyang⁴,Li Yimeng⁵,Huang Weiguo¹,Ni Haizhen¹,Lv Heping¹,Zhang Qiyu²

Affiliation:

1. Department of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, Zhejiang Province, China

2. Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, Zhejiang Province, China

3. First school of Clinical Medicine, Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China

4. Department of Hepatobiliary Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China

5. Key Laboratory of Diagnosis & Treatment of Severe Hepato-Pancreatic Diseases, The First Affiliated Hospital, Wenzhou Medical University, 325015, Zhejiang Province, China

Abstract

Aims: To develop a ferroptosis gene-based survival-predictor model for predicting the prognosis of patients with digestive tract tumors, a pan-caner analysis was performed. Materials & methods: Based on unsupervised clustering and the expression levels of ferroptosis genes, patients with cancer were divided into two clusters. The least absolute shrinkage and selection operator method Cox regression analysis was used to establish the survival-predictor model. Results: Based on the pan-cancer analysis, a 20 gene-based survival-predictor model for predicting survival rates was developed, which was validated in patients with hepatocellular carcinoma. Conclusion: The survival-predictor model accurately predicted the prognosis of patients with digestive tract tumors.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2021-0261

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