Activation of HCAR2 by niacin: benefits beyond lipid lowering-Reference-Cited by-同舟云学术

Activation of HCAR2 by niacin: benefits beyond lipid lowering

Published:2019-11 Issue:16 Volume:20 Page:1143-1150
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Tuteja Sony¹^ORCID

Affiliation:

1. Department of Medicine, Division of Translational Medicine & Human Genetics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, 11-143, Philadelphia, PA 19104, USA

Abstract

Niacin (nicotinic acid) is a potent lipid-lowering agent that has been used for prevention of coronary heart disease. Niacin activates the HCAR2 receptor found on adipocytes, macrophages and various immune cells throughout the body. Activation of the HCAR2 receptor by niacin results in beneficial anti-inflammatory effects that are independent of lipid lowering. This review summarizes the use of niacin in treatment of dyslipidemia, the pharmacogenetics of niacin response and the potential role of HCAR2 signaling in the treatment of a variety of inflammatory and metabolic diseases.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2019-0092

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