A census of RND superfamily proteins in the Burkholderia genus-Reference-Cited by-同舟云学术

A census of RND superfamily proteins in the Burkholderia genus

Published:2013-07 Issue:7 Volume:8 Page:923-937
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Perrin Elena¹,Fondi Marco¹²,Papaleo Maria Cristiana¹,Maida Isabel¹,Emiliani Giovanni³,Buroni Silvia⁴,Pasca Maria Rosalia⁴,Riccardi Giovanna⁴,Fani Renato⁵

Affiliation:

1. Laboratory of Molecular & Microbial Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino (Fi), Italy

2. Computer Laboratory, University of Cambridge, Cambridge, UK

3. Trees & Timber Institute, National Research Council, via Madonna del Piano, 10, 50019 Florence, Italy

4. Department of Biology & Biotechnology ‘Lazzaro Spallanzani’, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy

5. Laboratory of Molecular & Microbial Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino (Fi), Italy. .

Abstract

Aim: The aim of this work was to analyze the eight resistance–nodulation–cell division (RND) families (a group of proteins mainly involved in multidrug resistance of Gram-negative bacteria) in 26 Burkholderia genomes in order to gain knowledge regarding their presence and distribution, to obtain a platform for future experimental tests aimed to identify new molecular targets to be used in antimicrobial therapy against Burkholderia species and to refine the annotation of RND-like sequences in these genomes. Materials & methods: A total of 417 coding sequences were retrieved and analyzed using different bioinformatics tools. Results & conclusion: A complex pattern of RND presence and distribution in the different Burkholderia species was disclosed and a core of proteins represented in all 26 genomes was identified. These ‘core’ proteins might represent useful targets of new synthetic antimicrobial compounds. Furthermore, the annotation of RND-like sequences in Burkholderia was refined.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb.13.50

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