Multivariate analysis for coronary heart disease in heterozygote familial hypercholesterolemia patients

Author:

Sánchez Muñoz-Torrero Juan Francisco1,Rivas Maria D2,Zamorano Jose2,Joya-Vázquez Pedro Pablo3,de Isla Leopoldo Perez4,Padro Teresa5,Mata Pedro6,the SAFEHEART Investigators

Affiliation:

1. Department of Internal Medicine, Hospital San Pedro de Alcantara, Caceres, Spain

2. Research Unit, Hospital San Pedro de Alcantara, Caceres, Spain

3. Digestive Unit, Hospital General de Llerena, Llerena, Spain

4. Department of Cardiology, Hospital Clinico San Carlos, Madrid, Spain

5. Centro de Investigacion Cardiovascular CSIC-ICCC, Hospital Sant Pau & IIB-Sant Pau, & CIBEROBN, ISC III, Barcelona, Spain

6. Fundacion Hipercolesterolemia Familial, Madrid, Spain

Abstract

Aim: rs599839 polymorphism has been related with low levels of cholesterol and reduced coronary heart disease (CHD). Methods: We investigated the frequency of this polymorphism in patients with heterozygous familial hypercholesterolemia (HeFH) in the Spanish familial hypercholesterolemia cohort, 230 with and 202 without CHD. Results & discussion: A lower G-allele prevalence was observed in HeFH patients with CHD with respect to controls, 35 versus 45%, respectively (p = 0.029), suggesting a protective effect. However, it was found that there was no association between rs599839 alleles and CHD in the multivariate analysis. Conclusion: The frequency of the protective G-allele of the rs599839 polymorphism was lower in HeFH patients with CHD compared with those HeFH patients without CHD. However, its role in HeFH may be masked by very high levels of cholesterol.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

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