Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives

Author:

Ašić Adna1,Marjanović Damir12,Mirat Jure3,Primorac Dragan45678

Affiliation:

1. Department of Genetics & Bioengineering, International Burch University, Francuske revolucije bb, 71210 Ilidža, Sarajevo, Bosnia & Herzegovina

2. Institute for Anthropological Research, University of Zagreb, Ljudevita Gaja 32, 10000 Zagreb, Croatia

3. Polyclinic Kardioton, Kaptol 26, 10000 Zagreb, Croatia

4. St. Catherine Specialty Hospital, Zagreb & Zabok, Croatia

5. Eberly College of Science, 517 Thomas St, State College, Penn State University, PA 16803, USA

6. School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia

7. School of Medicine, University of Osijek, Ulica cara Hadrijana 10, 31000 Osijek, Croatia

8. Children's Hospital Srebrnjak, Srebrnjak 100, 10000 Zagreb, Croatia

Abstract

Novel oral anticoagulants (NOACs) are becoming a therapy of choice in everyday clinical practice after almost 50 years during which warfarin and related coumarin derivatives were used as the main anticoagulants. Advantages of NOACs over standard anticoagulants include their predictable pharmacodynamics and pharmacokinetics, stable plasma concentrations and less drug–drug and food–drug interactions. However, pharmacogenetics has its place in administration of NOACs, as considerable interindividual variations have been detected. In this review, previous findings in pharmacogenetics of dabigatran, rivaroxaban, apixaban and edoxaban are summarized, along with recommendations for studying genes encoding metabolically important enzymes for four selected NOACs. Future directions include identification of clinically relevant SNPs, and change in optimum dosage for patients who are carriers of significant variants.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

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