SARS-CoV-2: lessons from both the history of medicine and from the biological behavior of other well-known viruses

Author:

Fiorino Sirio1ORCID,Tateo Fabio2ORCID,Biase Dario De3ORCID,Gallo Claudio G4ORCID,Orlandi Paolo E5ORCID,Corazza Ivan6ORCID,Budriesi Roberta7ORCID,Micucci Matteo7ORCID,Visani Michela3ORCID,Loggi Elisabetta8ORCID,Hong Wandong9ORCID,Pica Roberta10ORCID,Lari Federico1ORCID,Zippi Maddalena10ORCID

Affiliation:

1. Internal Medicine Unit, Budrio Hospital, Budrio (Bologna), Azienda USL, Bologna, 40054, Italy

2. Institute of Geosciences & Earth Resources, CNR, c/o Department of Geosciences, Padova University, 35127, Italy

3. Department of Pharmacy & Biotechnology, University of Bologna, Bologna, 40126, Italy

4. Fisiolaserterapico Emiliano, Castel San Pietro Terme, Bologna, 40024, Italy

5. Unit of Radiology, Maggiore Hospital, Bologna, 40133, Italy

6. Department of Experimental, Diagnostic & Specialty Medicine, University of Bologna, Bologna, 40126, Italy

7. Department of Pharmacy & Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, 40126, Italy

8. Hepatology Unit, Department of Medical & Surgical Sciences, University of Bologna, Bologna, 40126, Italy

9. Department of Gastroenterology & Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang, 325035, PR China

10. Unit of Gastroenterology & Digestive Endoscopy, Sandro Pertini Hospital, Rome, 00157, Italy

Abstract

SARS-CoV-2 is the etiological agent of the current pandemic worldwide and its associated disease COVID-19. In this review, we have analyzed SARS-CoV-2 characteristics and those ones of other well-known RNA viruses viz. HIV, HCV and Influenza viruses, collecting their historical data, clinical manifestations and pathogenetic mechanisms. The aim of the work is obtaining useful insights and lessons for a better understanding of SARS-CoV-2. These pathogens present a distinct mode of transmission, as SARS-CoV-2 and Influenza viruses are airborne, whereas HIV and HCV are bloodborne. However, these viruses exhibit some potential similar clinical manifestations and pathogenetic mechanisms and their understanding may contribute to establishing preventive measures and new therapies against SARS-CoV-2.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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