Significance of broad-spectrum racemases for the viability and pathogenicity of <i>Aeromonas hydrophila</i>-Reference-Cited by-同舟云学术

Significance of broad-spectrum racemases for the viability and pathogenicity of Aeromonas hydrophila

Published:2022-03 Issue:4 Volume:17 Page:251-265
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Zhao Yi¹,Liu Yaoyao¹,Li Na¹,Muhammad Murtala²,Gong Siyu¹,Ju Jiansong¹,Cai Tongxuan¹,Wang Jialu¹,Zhao Baohua¹,Liu Dong¹^ORCID

Affiliation:

1. College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China

2. Department of Biochemistry, Kano University of Science and Technology, Wudil, 713281, Nigeria

Abstract

Aim: To investigate the function of broad-spectrum racemases in Aeromonas hydrophila (BsrA). Results: The A. hydrophila gene encoding BsrA ( bsr) mutants (AHΔbsr) exhibited a significant decrease in growth, motility, extracellular protease production and biofilm formation compared with the wild-type. Furthermore, bsr gene knockout instigated cell wall damage compared with the wild-type strains. The survival rate and replication capability in the blood and organs of the AHΔbsr-infected mice were significantly decreased. The degree of tissue injury in the AHΔbsr-infected group was lower than that of the wild-type-infected group. Moreover, there was a significant decrease in the expression of 12 AHΔbsr virulence genes. Conclusion: The bsr gene is essential for the viability and virulence of A. hydrophila.

Funder

Natural Science Foundation of Hebei Province

The Research Fund of Hebei Normal University

The Science and Technology Research Project of Hebei University

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2021-0112

Reference47 articles.

1. Differential production and secretion of potentially toxigenic extracellular proteins from hypervirulent Aeromonas hydrophila under biofilm and planktonic culture

2. Recombinant outer membrane protein OmpC induces protective immunity against Aeromonas hydrophila infection in Labeo rohita

3. Using quantitative polymerase chain reaction (qPCR) and occupancy models to estimate atypical Aeromonas hydrophila (aAh) prevalence in catfish

4. Identification of a new effector-immunity pair of Aeromonas hydrophila type VI secretion system

5. Virulence Factors of Aeromonas hydrophila: In the Wake of Reclassification

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transcriptome analysis of host anti-Aeromonas hydrophila infection revealed the pathogenicity of A. hydrophila to American eels (Anguilla rostrata);Fish & Shellfish Immunology;2024-05

2. A prototrophic suppressor of a Vibrio fischeri D-glutamate auxotroph reveals a member of the periplasmic broad-spectrum racemase family (BsrF);Journal of Bacteriology;2024-03-21