Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy-Reference-Cited by-同舟云学术

Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy

Published:2022-01 Issue:1 Volume:17 Page:5-15
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Kural Alev¹,Khan Imran²^ORCID,Seyit Hakan²,Caglar Tuba R²,Toklu Pınar²,Vural Meltem²

Affiliation:

1. Dr Sadi Konuk Research & Training Hospital, University of Health Sciences Bakırköy, Istanbul, Turkey

2. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Macau, People's Republic of China

Abstract

Aims: Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG. Methods & results: A total of 54 stool samples were collected from 27 morbidly obese individuals before and after LSG. The gut microbiota was profiled with 16S amplicon sequencing. After LSG, patients demonstrated a significant decrease (p < 0.001) in BMI and an increase in bacterial diversity. An increased Firmicutes/Bacteroidetes ratio was also noticed after LSG. The families Prevotellaceae and Veillonellaceae predominated in preoperative samples but were markedly lowered after LSG. A marked increase in Akkermansia, Alistipes, Streptococcus, Ruminococcus and Parabacteroides was observed after LSG. Conclusion: In addition to lowering BMI, LSG remodeled gut microbiota composition.

Funder

Fundo para o Desenvolvimento das Ciências e da Tecnologia

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2021-0043

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