Management of chronic Pseudomonas aeruginosa infection with inhaled levofloxacin in people with cystic fibrosis

Author:

Elborn J Stuart1ORCID,Flume Patrick A2ORCID,Van Devanter Donald R3ORCID,Procaccianti Claudio4

Affiliation:

1. Faculty of Medicine, Health & Life Sciences, Queen’s University Belfast, Belfast, BT9 7BL, UK

2. Departments of Medicine & Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA

3. Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA

4. Global Medical Affairs, Chiesi Farmaceutici S.p.A., Parma, 43122, Italy

Abstract

People with cystic fibrosis (CF) are highly susceptible to bacterial infections of the airways. By adulthood, chronic Pseudomonas aeruginosa ( Pa) is the most prevalent infective organism and is difficult to eradicate owing to its adaptation to the CF lung microenvironment. Long-term suppressive treatment with inhaled antimicrobials is the standard care for reducing exacerbation frequency, improving quality of life and increasing measures of lung function. Levofloxacin (a fluoroquinolone antimicrobial) has been approved as an inhaled solution in Europe and Canada, for the treatment of adults with CF with chronic P. aeruginosa pulmonary infections. Here, we review the clinical principles relating to the use of inhaled antimicrobials and inhaled levofloxacin for the management of P. aeruginosa infections in patients with CF.

Funder

Chiesi Farmaceutici,

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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