Enhanced biostability of nanoparticle-based drug delivery systems by albumin corona

Abstract

Aims: The long-term efficacy of nanoparticles is limited by their rapid metabolism in tissues. In this work, we aim to enhance nanoparticle biostability by preforming a bovine serum albumin (BSA) corona. Materials & methods: A BSA corona was formed by incubating poly-3-hydroxybutyrate-co-3-hydroxyhexanoate nanoparticles with BSA solution and confirmed by SDS-PAGE and x-ray photoelectron spectroscopy. The impacts of the BSA corona on the drug release, biostability and biodistribution of nanoparticles were investigated. Results: In the presence of the BSA corona, the drug release (coumarin-6 was used as the model drug) of nanoparticles was significantly slower and their stability in liver homogenate and in organs was enhanced. Conclusion: Preformation of a BSA corona may be a promising approach for enhancing drug biostability and for developing long-acting nanoparticle formulations. Original submitted 25 February 2014; Revised submitted 10 April 2014