Stimuli-responsive smart nanogels for cancer diagnostics and therapy-Reference-Cited by-同舟云学术

Stimuli-responsive smart nanogels for cancer diagnostics and therapy

Published:2010-04 Issue:3 Volume:5 Page:451-468
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Oishi Motoi¹²³,Nagasaki Yukio¹²³⁴⁵

Affiliation:

1. Tsukuba Interdisciplinary Materials Science (TIMS), University of Tsukuba, 1–1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan.

2. Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan

3. Graduate School of Pure and Applied Sciences, University of Tsukuba, Japan

4. Master’s School of Medical Sciences, University of Tsukuba, Japan

5. International Center for Materials Nanoarchitectonics Satellite (MANA), National Institute for Materials Science (NIMS) and University of Tsukuba, Japan

Abstract

This article discusses stimuli-responsive poly(ethylene glycol) (PEG)-coated (PEGylated) nanogels and their biomedical applications. Preparation and characterization of stimuli-responsive PEGylated nanogels composed of a crosslinked poly(2-[N,N-diethylamino]ethyl methacrylate) (PEAMA) core and PEG tethered chains are initially described. Stimuli-responsive PEGylated nanogels show unique properties and functions in synchronizing with the reversible volume phase transition of the PEAMA core in response to the extracellular pH (7–6.5) of a tumor environment as well as endosomal/lysosomal pH (6.5–5.0) and temperature. We list several biomedical applications of stimuli-responsive PEGylated nanogels, including 19F magnetic resonance spectroscopic imaging (MRS/I) probe to visualize acidosis (tumor tissue), intracellular drug and siRNA delivery, antennas for cancer photothermal therapy and apoptosis probe for monitoring response to cancer therapy. Thus, stimuli-responsive PEGylated nanogels can be utilized as smart nanomedicines for cancer diagnostics and therapy.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm.10.18

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